| SPO | Sacramento Peak Observatory 
| Others |
| SPO | Saint Paul's Outreach
| Others |
| SPO | Sales Performance Optimization
| Others |
| SPO | Sales Promotion Office
| Others |
| SPO | Scale Polarize Offset
| Others |
| SPO | Schizosaccharomyces Pombe
| Others |
| SPO | Scientific Program Overview
| Others |
| SPO | Scientific Publications Office
| Others |
| SPO | Secondary Public Offering
| Others |
| SPO | Security and Plans Officer
| Others |
| SPO | Security Police Officer
| Others |
| SPO | Security, Plans, and Operations
| Others |
| SPO | Sektorowe Programy Operacyjne (Polish: Sectoral Operational Program)
| Others |
| SPO | Self Prediction Optimality
| Others |
| SPO | Senate Press Office (Georgia)
| Others |
| SPO | Sendai Philharmonic Orchestra
| Others |
| SPO | Senior Patrol Officer
| Others |
| SPO | Senior Planning Officer
| Others |
| SPO | Senior Police Officer
| Others |
| SPO | Senior Programme Officer
| Others |
| SPO | SEO Product Optimizer
| Others |
| SPO | Seoul Philharmonic Orchestra
| Others |
| SPO | Service Parts Operation
| Others |
| SPO | Service Parts Operations
| Others |
| SPO | Service Point Oriflame
| Others |
| SPO | Service Process Optimization
| Others |
| SPO | Service Provider Organization
| Others |
| SPO | Servicing Personnel Office
| Others |
| SPO | Serving Post Office
| Others |
| SPO | Shanghai Philharmonic Orchestra
| Others |
| SPO | Share Point Online
| Others |
| SPO | Sharepoint Online
| Others |
| SPO | SharePoint Protocols Overview
| Others |
| SPO | Shippensburg Produce and Outreach
| Others |
| SPO | Shore Patrol Officer
| Others |
| SPO | Sick Psycho Obsessive
| Others |
| SPO | Sigma Phi Omega
| Others |
| SPO | Sign Performance Outreach
| Others |
| SPO | Single Point Of Failure
| Others |
| SPO | Single Purpose Outlet
| Others |
| SPO | Single-Pilot Operation
| Others |
| SPO | Slaithwaite Philharmonic Orchestra
| Others |
| SPO | Slovak Philharmonic Orchestra
| Others |
| SPO | Small Pack Option
| Others |
| SPO | Small Project Observatory
| Others |
| SPO | Smith Petersen osteotomy
| Others |
| SPO | Smith-Peterson Osteotomy
| Others |
| SPO | Social Policy Obligations
| Others |
| SPO | Solmonese Parents Organization
| Others |
| SPO | South Pole Observatory
| Others |
| SPO | Space Pirate Organization
| Others |
| SPO | Space Planning and Operations
| Others |
| SPO | Space Planning Operations
| Others |
| SPO | Space Program Office
| Others |
| SPO | Spare Parts Order
| Others |
| SPO | Special Palm Oil
| Others |
| SPO | Special Police Officer
| Others |
| SPO | Special Production Option
| Others |
| SPO | Special Programs Office
| Others |
| SPO | Special Project Office
| Others |
| SPO | Special Project Officer
| Others |
| SPO | Special Projects Office
| Others |
| SPO | Spokane, Washington
| Others |
| SPO | Sponsored Programs Office
| Others |
| SPO | Sponsored Project Office
| Others |
| SPO | Sponsored Projects Office
| Others |
| SPO | Sportabout
| Others |
| SPO | Srpski Pokret Obnove (Serbian: Serbian Renewal Movement; political party created in 1990)
| Others |
| SPO | Staffware Process Objects
| Others |
| SPO | Standard Pascal Object
| Others |
| SPO | Standardized Purchase Order
| Others |
| SPO | Standing Purchase Order
| Others |
| SPO | State Personnel Office
| Others |
| SPO | State Planning Office
| Others |
| SPO | State Procurement Office
| Others |
| SPO | State Property Office
| Others |
| SPO | Statutory Publications Office
| Others |
| SPO | Stoker Petty Officer
| Others |
| SPO | Strategic Partnerships Office
| Others |
| SPO | Strategic Plan Objectives
| Others |
| SPO | Strategic Planning Officer
| Others |
| SPO | Strengthening Participatory Organisation
| Others |
| SPO | Structure, Process and Outcome
| Others |
| SPO | Student Peace Organization
| Others |
| SPO | Student Performance Objectives
| Others |
| SPO | Student Police Officer
| Others |
| SPO | Student Post Office
| Others |
| SPO | Student Production Office
| Others |
| SPO | Student Professional Organization
| Others |
| SPO | Sub Post Office
| Others |
| SPO | Super Production Over
| Others |
| SPO | Supervisory Police Officer
| Others |
| SPO | Supplier Purchase Order
| Others |
| SPO | Supply Path Optimisation
| Others |
| SPO | Supply Path Optimization
| Others |
| SPO | Sustainability Performance Office
| Others |
| SPO | System Program Office
| Others |
| SPO | System Project Office
| Others |
| SPO | Systems Program Office
| Others |