| SPE | Sanitas Per Escam 
| Others |
| SPE | Sauber Petronas Engineering
| Others |
| SPE | Saw Palmetto Extract
| Others |
| SPE | Scattered Photon Extraction
| Others |
| SPE | Scientia Potentia Est
| Others |
| SPE | Semiconductor Product Equipment
| Others |
| SPE | Sepulot, Sabah, Malaysia
| Others |
| SPE | Serial Parallel Expansion
| Others |
| SPE | Serial Peripheral System Enable
| Others |
| SPE | Serial Platform Emulator
| Others |
| SPE | Serum Protein Electrophoresis
| Others |
| SPE | Service Processing Element
| Others |
| SPE | Service Procurement Engineering
| Others |
| SPE | Service Provider Equipment
| Others |
| SPE | Single Pair Ethernet
| Others |
| SPE | Single Point Entry
| Others |
| SPE | Single Point of Entry
| Others |
| SPE | Single Purpose Entity
| Others |
| SPE | Skill Performance Evaluation
| Others |
| SPE | Slightly Pointed East
| Others |
| SPE | Small Product Enhancement
| Others |
| SPE | Small Programming Enhancement
| Others |
| SPE | Smart Performance Economy
| Others |
| SPE | Societas Privata Europaea
| Others |
| SPE | Society for Photographic Education
| Others |
| SPE | Society of Petroleum Engineers
| Others |
| SPE | Society of Plastic Engineers
| Others |
| SPE | Society of Plastics Engineers
| Others |
| SPE | Software Port Entity
| Others |
| SPE | Software Practice and Experience
| Others |
| SPE | Solar Proton Event
| Others |
| SPE | Solid Phase Extraction
| Others |
| SPE | Solid Polymer Electrolysis
| Others |
| SPE | Sony Pictures Entertainment
| Others |
| SPE | Sound Pattern of English
| Others |
| SPE | South African Society for Professional Engineers
| Others |
| SPE | Southern Peripheral Expressway
| Others |
| SPE | Southern Pipeline Extension
| Others |
| SPE | Spanish Proficiency Exercises
| Others |
| SPE | Spare Parts Expert
| Others |
| SPE | Spatzle Processing Enzyme
| Others |
| SPE | Special Police Establishment
| Others |
| SPE | Special Programming Enhancements
| Others |
| SPE | Special Purpose Entity
| Others |
| SPE | Spirit es
| Others |
| SPE | Spline Editor
| Others |
| SPE | Stadia Premiere Edition
| Others |
| SPE | Stani's Python Editor
| Others |
| SPE | Statement of Performance Expectation
| Others |
| SPE | Static Phase Error
| Others |
| SPE | Storage Processor Enclosure
| Others |
| SPE | Strength Power and Endurance
| Others |
| SPE | Student Program Element
| Others |
| SPE | Summit Pointe Elementary
| Others |
| SPE | Supplier Performance Evaluation
| Others |
| SPE | Surface Preparation Equipment
| Others |
| SPE | Swedish Penis Enlarger
| Others |
| SPE | Sweq Player Experience
| Others |
| SPE | Switching Provider Edge
| Others |
| SPE | Symantec Protection Engine
| Others |
| SPE | Synchronous Payload Envelope
| Others |
| SPE | Synergistic Processing Element
| Others |
| SPE | Synergistic Processing Engine
| Others |
| SPE | System Policy Editor
| Others |
| SPE | System Processing Engine
| Others |