| RLE | Rail Liaison Element 
| Others |
| RLE | Ralph Lee Earnhardt
| Others |
| RLE | Real Life Example
| Others |
| RLE | Rear-Engined Low Entry Bus
| Others |
| RLE | Red Letter Edition
| Others |
| RLE | Red Letter Events
| Others |
| RLE | Redesigned Learning Environments
| Others |
| RLE | Refractive Lens Exchange
| Others |
| RLE | Registro e Licenciamento de Empresas
| Others |
| RLE | Related Learning Experience
| Others |
| RLE | Reliant le
| Others |
| RLE | Required Local Effort
| Others |
| RLE | Research Laboratory of Electronics
| Others |
| RLE | Research Laboratory of Electronics at MIT
| Others |
| RLE | Respect, Loyalty, Entertainment
| Others |
| RLE | Return Link End
| Others |
| RLE | Review Level Earthquake
| Others |
| RLE | Right Lower Extremities
| Others |
| RLE | Right Lower Extremity
| Others |
| RLE | Right to Left Embedding
| Others |
| RLE | Roadster Limited Edition
| Others |
| RLE | Robert Lee Entertainment
| Others |
| RLE | Rocket League Edition
| Others |
| RLE | Rotating Linear Engine
| Others |
| RLE | Run Language Encoding
| Others |
| RLE | Run Length Encoded
| Others |
| RLE | Run Length Encoded file
| Others |
| RLE | Run Length Encoding
| Others |
| RLE | Run-Length Encoding
| Others |
| RLE | Utah Run-Length Encoded image file Bitmap graphics
| Others |
| RLE | Windows or CompuServe RLE image format
| Others |