| OSU | Observational Stimulation Unit 
| Others |
| OSU | Official Soviet University
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| OSU | Officially Sanctioned User
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| OSU | Ohio State
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| OSU | Ohio State Ohio State
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| OSU | Ohio State University
| Others |
| OSU | Ohio State University's
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| OSU | Ohio Sux Undeniably
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| OSU | Oklahoma Scares Us
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| OSU | Oklahoma Second University
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| OSU | Oklahoma State University
| Others |
| OSU | Oklahoma State UniversityOklahoma State University
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| OSU | Old Stinky Under
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| OSU | Old Stinky Underwear
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| OSU | Old-style Soviet University
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| OSU | Onomastic Studies Unit
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| OSU | Open Source Unix
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| OSU | Open System Utilities
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| OSU | Optical Scan Unit
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| OSU | Optical Service Unit
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| OSU | Optical Subscriber Unit
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| OSU | Optical Switching Unit
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| OSU | Optimists Submit Urine
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| OSU | Oracle Software Upgrade
| Others |
| OSU | Orangatang Socializing University
| Others |
| OSU | Oregon Second-rate University
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| OSU | Oregon Snowflake University
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| OSU | Oregon Soviet University
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| OSU | Oregon Spam University
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| OSU | Oregon State University
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| OSU | Oregon State University's
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| OSU | Organized Socialist University
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| OSU | Oscillating Sumo Understanding
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| OSU | Other Software Unit
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| OSU | Outstanding Satisfactory Or Unsatisfactory
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| OSU | Outstanding Satisfactory Unsatisfactory
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| OSU | Overated State University
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| OSU | Overrated State University
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| OSU | Ursuline Sisters of the Roman Union
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| OSU! | 1) A term used in karate. 2) A popular game originally released by Microsoft.
| Others |