| OSF | Franciscan Sisters (Allegany) 
| Others |
| OSF | Object Strike Force
| Others |
| OSF | Observed Support Frequency
| Others |
| OSF | Off Side Front
| Others |
| OSF | Off-Side Front
| Others |
| OSF | Office of Space Flight
| Others |
| OSF | Office of State Finance
| Others |
| OSF | Old Skool Ford
| Others |
| OSF | Old Spaghetti Factory
| Others |
| OSF | Old Style Figures
| Others |
| OSF | Omaha Schools Foundation
| Others |
| OSF | On Scene Forces
| Others |
| OSF | One Sexy F***er
| Others |
| OSF | One Step Further
| Others |
| OSF | Open Science Framework
| Others |
| OSF | Open Security Framework
| Others |
| OSF | Open Semantic Framework
| Others |
| OSF | Open Society Foundations
| Others |
| OSF | Open Software Foundation
| Others |
| OSF | Open Source File
| Others |
| OSF | Open Source Folder
| Others |
| OSF | Open Source Folks
| Others |
| OSF | Open Stack Foundation
| Others |
| OSF | Open System Foundation
| Others |
| OSF | Open Systems Foundation
| Others |
| OSF | Operation Support Facility
| Others |
| OSF | Operational Support Facility
| Others |
| OSF | Operational Support Facility ( Orlando)
| Others |
| OSF | Operations Support Facility
| Others |
| OSF | Operations System Function
| Others |
| OSF | Optimal Solutions Found
| Others |
| OSF | Order of Saint Francis
| Others |
| OSF | Order Of St Francis
| Others |
| OSF | Order Sorted Featured
| Others |
| OSF | Order Sorting Filter
| Others |
| OSF | Ordinateurs Sans Frontieres
| Others |
| OSF | Ordnance Storage Facility
| Others |
| OSF | Oregon Shakespeare Festival
| Others |
| OSF | Oregon Shakespere Festival
| Others |
| OSF | Organ System Failure
| Others |
| OSF | Orphaned Starfish Foundation
| Others |
| OSF | Osaka Stock Futures 50
| Others |
| OSF | Other Safety Features
| Others |
| OSF | Our Soccer Field
| Others |
| OSF | Outrage Sound Format
| Others |
| OSF | Outsourcing Factory
| Others |
| OSF | Over Sampling Factor
| Others |
| OSF | Saint Francis
| Others |
| OSF | sisters of St. Francis of Philadelphia
| Others |
| OSF | St Francis
| Others |