| MSPE | M Sc in Power Engineering 
| Others |
| MSPE | Massachusetts Society of Professional Engineers
| Others |
| MSPE | Master of Science for Professional Educators
| Others |
| MSPE | Mean Square Prediction Error
| Others |
| MSPE | Mean Squared Prediction Error
| Others |
| MSPE | Mean Squared Pure Error
| Others |
| MSPE | Medical School Performance Evaluation
| Others |
| MSPE | Medical Student Performance Evaluation
| Others |
| MSPE | Mercenaries, Spies and Private Eyes
| Others |
| MSPE | Michigan Society of Professional Engineers
| Others |
| MSPE | Microsoft Project English
| Others |
| MSPE | Mindful Sport Performance Enhancement
| Others |
| MSPE | Minnesota Society of Professional Engineers
| Others |
| MSPE | Missouri Society of Professional Engineers
| Others |
| MSPE | Mobile Services and Personalized Environments
| Others |