| MDE | Major Depressive Episode 
| Others |
| MDE | Major Design Element
| Others |
| MDE | Managing Data Efficiently
| Others |
| MDE | Manual Data Entry
| Others |
| MDE | Maritime Data Engine
| Others |
| MDE | Market Development Engineering
| Others |
| MDE | Maryland Department of the Environment
| Others |
| MDE | Mass Deviation Effect
| Others |
| MDE | Master in Design Engineering
| Others |
| MDE | Master of Distance Education
| Others |
| MDE | Masters Direct Entry
| Others |
| MDE | Mastery Delivery And Excellence
| Others |
| MDE | Maximum Design Earthquake
| Others |
| MDE | Mcafee Drive Encryption
| Others |
| MDE | MDE database ( Microsoft Access)
| Others |
| MDE | Medellin, Colombia
| Others |
| MDE | Media Disk Encryption
| Others |
| MDE | Medium Diesel Engine
| Others |
| MDE | Meta Data Explorer
| Others |
| MDE | Michelin Driving Experience
| Others |
| MDE | Michigan Department of Education
| Others |
| MDE | Microsoft Data Engine
| Others |
| MDE | Microsoft Database Executable
| Others |
| MDE | Microsoft Development Environment
| Others |
| MDE | Military Dynasty Elimination
| Others |
| MDE | Million Dollar Extreme
| Others |
| MDE | Mini Driving Experience
| Others |
| MDE | Minimum Detectable Effect
| Others |
| MDE | Minimum Distributor Earnings
| Others |
| MDE | Minnesota Department of Education
| Others |
| MDE | Mission Dependent Equipment
| Others |
| MDE | Mission Dependent Experiment
| Others |
| MDE | Mississippi Department of Education
| Others |
| MDE | Mitsubishi Design Europe
| Others |
| MDE | Model Driven Engineering
| Others |
| MDE | Modelos De Elevaci
| Others |
| MDE | Modular Design Environment
| Others |
| MDE | Modular Display Electronics
| Others |
| MDE | Most Disappointing Effort
| Others |
| MDE | Motor Drive End
| Others |
| MDE | Multimedia Delivery Europe
| Others |
| MDE | Multiple Design Environment
| Others |
| MDE | Multiple Document Environment
| Others |
| MDE | My Disney Experience
| Others |