| ISRS | In-Structure Response Spectra 
| Others |
| ISRS | Information Storage And Retrieval System
| Others |
| ISRS | Integrated Statewide Records System
| Others |
| ISRS | Intelligent Supplemental Restraint System
| Others |
| ISRS | International Safety Rating System
| Others |
| ISRS | International Society for Reef Studies
| Others |
| ISRS | International Society for River Science
| Others |
| ISRS | International Society of Refractive Surgeons
| Others |
| ISRS | International Society of Refractive Surgery
| Others |
| ISRS | International Sports Racing Series
| Others |
| ISRS | International Stereotactic Radiosurgery
| Others |
| ISRS | International Stereotactic Radiosurgery Society
| Others |
| ISRS | International Student Retention Scholarship
| Others |
| ISRS | International Symposium on Radiopharmaceutical Sciences
| Others |
| ISRS | International Symposium on Road Safety
| Others |
| ISRS | Intro Stat with Randomization and Simulation
| Others |
| ISRS | Intro Statistics with Randomization and Simulation
| Others |