| HPE | Hattrick Press Editor 
| Others |
| HPE | Health and People Exercising
| Others |
| HPE | Health Professional Education
| Others |
| HPE | Health Promotion Education
| Others |
| HPE | Health Promotion England
| Others |
| HPE | Health Promotion England (abolished, date unknown)
| Others |
| HPE | Helping People Everywhere
| Others |
| HPE | Hennessey Performance Engine
| Others |
| HPE | Hennessey Performance Engineering
| Others |
| HPE | hepatoportoenterostomy
| Others |
| HPE | Hewlett Packard Enterprise
| Others |
| HPE | High Performance and Excellence
| Others |
| HPE | High Performance Edition
| Others |
| HPE | High Performance Engineering
| Others |
| HPE | High Performance Engines
| Others |
| HPE | High Performance Environment
| Others |
| HPE | High Performance Equipment
| Others |
| HPE | High Performance Estate
| Others |
| HPE | High Performance Ethernet
| Others |
| HPE | High Performance Executive
| Others |
| HPE | High Potential Elements
| Others |
| HPE | Higher Professional Education
| Others |
| HPE | Highland Park Elementary
| Others |
| HPE | histopathological examination
| Others |
| HPE | History and Physical Examination
| Others |
| HPE | holoprosencephaly
| Others |
| HPE | Honda Power Equipment
| Others |
| HPE | Honoring Past Experience
| Others |
| HPE | Hope Vale, Queensland, Australia
| Others |
| HPE | Horse Power Engineering
| Others |
| HPE | HTTP Parse Error
| Others |
| HPE | Human Performance Engineering
| Others |
| HPE | Human Phisiological Equivalent
| Others |
| HPE | Human Post Effects
| Others |
| HPE | Humble Portal Engine
| Others |
| HPE | Hydraulic Pump Mounted to an Engine
| Others |
| HPE | hydrostatic pulmonary (o)edema
| Others |
| HPE | Hypericum perforatum extract
| Others |