| ESDC | Educational Support and Distribution Center 
| Others |
| ESDC | Eighteenth Street Development Corporation
| Others |
| ESDC | Electronic Systems Design Centre
| Others |
| ESDC | Empire State Development Corporation
| Others |
| ESDC | Employment and Social Development Canada
| Others |
| ESDC | Engineering Services for Design and Construction
| Others |
| ESDC | Engineering Student Design Center
| Others |
| ESDC | Esac Science Data Centre
| Others |
| ESDC | Eurasian Schools Debating Championships
| Others |
| ESDC | European Security and Defence College
| Others |
| ESDC | European Swing Dance Championships
| Others |
| ESDC | Expressing Simple Dublin Core
| Others |