| DESC | Dark Energy Science Collaboration 
| Others |
| DESC | Defense Electronics Supply Center
| Others |
| DESC | Defense Energy Support Center
| Others |
| DESC | Descender
| Others |
| DESC | Descending
| Others |
| DESC | DESCent
| Others |
| DESC | Describe Explain Support and Collaborate
| Others |
| DESC | Describe Express Specific Consequences
| Others |
| DESC | Describe Express Specify And Consequences
| Others |
| DESC | Describe Express Specify Consequences
| Others |
| DESC | Design Evaluation Services for Client
| Others |
| DESC | Desktop Connection
| Others |
| DESC | Detroit Employment Solutions Corporation
| Others |
| DESC | Detroit Executive Service Corps
| Others |
| DESC | Development of Earth Science Curricula
| Others |
| DESC | Development of Externalizing Self Control
| Others |
| DESC | Diagnose, Eliminate, Slow, and Cancel
| Others |
| DESC | Digital Employment Sales Center
| Others |
| DESC | Digital Environment for Sample Curation
| Others |
| DESC | Direct Clutch Control
| Others |
| DESC | Direct Electronic Shift Control
| Others |
| DESC | Discover Engineering Summer Camp
| Others |
| DESC | Distance Education Service Center
| Others |
| DESC | Distributed Energy Systems Corporation
| Others |
| DESC | District Explorer Scout Commissioner
| Others |
| DESC | Downtown Ecumenical Services Council
| Others |
| DESC | Downtown Emergency Service Center
| Others |
| DESC | Drainage Erosion and Sediment Control
| Others |
| DESC | Dubai English Speaking College
| Others |