| S | Superuser 
| Others |
| S | Support
| Others |
| S | Survival Mode
| Others |
| S | Susan
| Others |
| S | Suspension
| Others |
| S | Sweep
| Others |
| S | Sweet
| Others |
| S | Symbol
| Others |
| S & E | Safety and Effectiveness
| Others |
| S Afr Med J | South African Medical Journal (Capetown)
| Others |
| S CHG | Supercharge
| Others |
| S PRES | Star Present
| Others |
| S SCAN | Sector Scan
| Others |
| S TRK | Star Tracker
| Others |
| S# | Sheldon Number
| Others |
| S# | Snow Number
| Others |
| S$$ | Temporary sort file (Sprint)
| Others |
| S&A | Safe and Arm (Device)
| Others |
| S&A | Safety and Arming
| Others |
| S&A | Science and Application
| Others |
| S&A | Simulation and Analysis
| Others |
| S&A | Sonya And Natasha
| Others |
| S&A | Stewart and Arden
| Others |
| S&A | Sugar and acetone
| Others |
| S&A | Supervision & Administration
| Others |
| S&A | Synonyms & Antonyms
| Others |
| S&AD | Science and Applications Directorate
| Others |
| S&AE | Stamping and Assembly Engineering
| Others |
| S&B | Shot and a Beer
| Others |
| S&B | Sibona e Basano
| Others |
| S&C | Safety and Control
| Others |
| S&C | Stability and Control
| Others |
| S&C | Survey and Certification
| Others |
| S&D | Sales & Distribution
| Others |
| S&D | Schiel & Denver Book Publishers
| Others |
| S&D | Search and Destroy
| Others |
| S&E | Science and Engineering
| Others |
| S&E | Science and Engineering (MSFC Directorate)
| Others |
| S&E | Service and Equipment
| Others |
| S&F | Slip and Fall
| Others |
| S&F | Store and Forward
| Others |
| S&F | Store-And-Forward
| Others |
| S&G | Services and Goods
| Others |
| S&G | Stop and Go
| Others |
| S&GAD | Services and General Administration Department
| Others |
| S&GOM | Sales and General Operations Manager
| Others |
| S&GSLCMC | Soldier and Ground Systems Life Cycle Management Command
| Others |
| S&H | Safety and Health
| Others |
| S&H | Sand and Highway
| Others |
| S&H | Science and Health
| Others |