| S2 | Seaman 2nd Class 
| Others |
| S2 | Shrek 2
| Others |
| S2 | Shuttle 2
| Others |
| S21BR | Sierra Twenty one Bravo Romeo, Bangladesh
| Others |
| S24 | Sandusky County Regional Airport, Fremont, Ohio USA
| Others |
| S28D | Society of the 28th Division Allied Expeditionary Forces
| Others |
| S2A | Scan to Application
| Others |
| S2A | Silicon Storage Appliance
| Others |
| S2B | Service to Business
| Others |
| S2C | Send to Car
| Others |
| S2C | Service to Consumer
| Others |
| S2D | Storage Spaces Direct
| Others |
| S2E | Scan to e-Mail
| Others |
| S2E | Seamless Synthetic Environment
| Others |
| S2E | Silhouette 2wd Extended
| Others |
| S2E | Small Conventional Cab 4x2 Extended
| Others |
| S2ERC | Security and Software Engineering Research Center
| Others |
| S2ESC | Software and Systems Engineering Standards Committee
| Others |
| S2G | Swear to God
| Others |
| S2K | Sport 2000
| Others |
| S2K | Super 2000
| Others |
| S2K | System 2000
| Others |
| S2KI | Honda S2000 International
| Others |
| S2KICOM | Honda S2000 International Community
| Others |
| S2KKCC | Honda S2000 Kansas City Club
| Others |
| S2L | Silhouette 2wd Luxury
| Others |
| S2L | Sunbird 2000 Le
| Others |
| S2M | Schedule to Mobile
| Others |
| S2M | Send to Mobile
| Others |
| S2ML | Security Services Markup Language
| Others |
| S2MP | Scalable Shared Memory Multiprocessor
| Others |
| S2MP | Scalable Symmetrical Multi Processing
| Others |
| S2P | Scan to Palm
| Others |
| S2P | Secondary State Pension
| Others |
| S2P | Source-2-Pay
| Others |
| S2P | String to Print
| Others |
| S2R | Send to Receive (pictures)
| Others |
| S2R | Send to Recieve
| Others |
| S2RV | Safety Scientific Research Vehicle
| Others |
| S2S | Server to Server
| Others |
| S2S | Side to Side
| Others |
| S2S | Site to Site
| Others |
| S2S | Sunbird 2000 Se
| Others |
| S2S | System to System
| Others |
| S2U | Same To You
| Others |
| S2V | Sensor to Vehicle
| Others |
| S2V | Solar to Vehicle
| Others |
| S2V | Speed To Value
| Others |
| S2V | Streetcar to Vehicle
| Others |
| S2V | Surface to Vehicle
| Others |