| I/T | Intrathecal  
| Medical |
| I/V | Inlet Valve
| Hardware |
| I03 | Information Object Oriented Obsidian 3
| Computer Programming |
| I0M | I Owe Money
| Finance |
| I18N | Indiana route 18 North
| Route |
| I18N | Internationalization
| Computer Programming, Marketing |
| I2 | Image Intensification
| Technology |
| I2 | Internet 2
| Internet |
| I2 | Ion Implant (also seen as II)
| Technology |
| I23 | Fayette County Airport, Washington Court House, Ohio USA
| Airport |
| I2A | Insights to Action
| Technology, Analytics |
| I2A2 | Infrastructure for Identification Authentication and Authorization
| Computing, Security |
| I2C | Information Copy Control
| Computing |
| I2C | Infrastructure to Car
| Technology, Transport |
| I2C | Intelligent Controller
| Technology, Computing |
| I2C | Inter Integrated Circuit
| Others |
| I2C | Inter-Integrated Circuit
| Technology |
| I2CEWS | Intelligence Information Cyber Electronic Warfare and Space
| Military |
| I2G | Immune 2 Greed
| Computing |
| I2I | Infrastructure to Infrastructure
| Others |
| I2L | Integrated Injection Logic
| Electronics |
| I2L | Integrated Injector Logic
| Others |
| I2M | Idea to Market
| Business, Entrepreneurship |
| I2M | Integrated Internet Marketing
| Marketing |
| I2NSF | Interfaces to Network Security Functions
| Computing |
| I2O | Intelligent Input Output
| Others |
| I2O | Intelligent Input/Output
| Computing |
| I2OR | International Institute of Organized Research
| Institute |
| I2P | Invisible Internet Project
| Software |
| I2POS | Internet to Point of Sale
| Sales |
| I2R | Imaging Infrared
| Technology |
| I2S | Inter Ic Sound
| Others |
| I2S | Inter-IC Sound
| Technology |
| I2SF | International Information Security Foundation
| Education, Internet, Technology, Security |
| I2T | Image to Text
| Technology |
| I2TL | Introduction to Transformer Losses
| Others |
| I2V | Infrastructure to Vehicle
| Technology, Transport |
| I2V | Invisible to Visible
| Technology, Transport |
| I2VC | Infrastructure to Vehicle Communication
| Technology, Transport |
| I2W | Independent Double Wishbone
| Hardware, Transport |
| i2z | Information Inquiry Independan2z
| Others |
| I3 | Interface source (Modula-3)
| Programming Language |
| I300I | International 300mm Initiative
| Others |
| I3A | Indole-3-Acetonitrile
| Chemistry, Chemical Compound |
| I3A | Installation Information Infrastructure Architecture
| Military |
| I3A | International Imaging Industry Association
| Organization |
| I3C | In Car Customer Communication
| Technology, Transport |
| I3C | Innocenti Tre Cilindri
| Transport |
| I3D | Interactive Three Dimensional
| Technology |
| I3DL2 | Interactive Three Dimensional Audio Level Two
| Others |